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Opinion|Videos|October 21, 2024

Overview of the CAPItello-291 Trial

Author(s)Joyce O’Shaughnessy, MD, Laura Huppert, MD, Heather Moore, Pharm D

Panelists discuss the findings of the CAPItello-291 trial, which investigated capivasertib combined with fulvestrant in advanced hormone receptor–positive, HER2-negative breast cancer, leading to its approval in November 2023 and highlighting its potential as a new targeted therapy option in the second-line setting due to the prevalence of PIK3CA, AKT1, and PTEN alterations.

Episodes in this series

EP. 1 Insights on Biomarker Testing in HR+/HER2- Advanced Breast Cancer

EP. 1 Insights on Biomarker Testing in HR+/HER2- Advanced Breast Cancer

EP. 2 First-Line Treatment Strategies for HR+/HER2- Advanced Breast Cancer

EP. 2 First-Line Treatment Strategies for HR+/HER2- Advanced Breast Cancer

EP. 3 Role of PI3K/AKT/PTEN Pathway in HR+/HER2- Advanced Breast Cancer

EP. 3 Role of PI3K/AKT/PTEN Pathway in HR+/HER2- Advanced Breast Cancer

EP. 4 Overview of the CAPItello-291 Trial

EP. 4 Overview of the CAPItello-291 Trial

EP. 5 Clinical Experience with Capivasertib

EP. 5 Clinical Experience with Capivasertib

EP. 6 Adverse Event Management: Strategies for Reducing Diarrhea Risk in Capivasertib Therapy

EP. 6 Adverse Event Management: Strategies for Reducing Diarrhea Risk in Capivasertib Therapy

EP. 7 Managing Capivasertib Side Effects: Strategies for Educating, Monitoring, and Addressing Rash and Hyperglycemia

EP. 7 Managing Capivasertib Side Effects: Strategies for Educating, Monitoring, and Addressing Rash and Hyperglycemia

EP. 8 Best Practices in Managing Patients on Capivasertib

EP. 8 Best Practices in Managing Patients on Capivasertib

Video content above is prompted by the following:

Dr Huppert: Please summarize the findings of the CAPItello-291 trial investigating capivasertib plus fulvestrant in the advanced hormone receptor–positive, HER2- negative setting, which led to its approval in November 2023. Turner NEJM 2023
Given the frequency of P13KCA, AKT1, and PTEN alterations, how does capivasertib plus fulvestrant represent a new targeted therapy option in the second-line setting?
Dr Huppert: What patient factors do you consider when initiating patients on capivasertib?

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