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Opinion|Videos|January 16, 2026

Persisting Questions in ER+ Breast Cancer in the Second Line and Beyond

Author(s)Hope S. Rugo, MD, Seth Wander, MD, PhD

Experts discuss the future of breast cancer treatment, emphasizing personalized approaches and the potential of new oral therapies to improve outcomes.

Episodes in this series

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

2 experts in this video

EP. 3 The Impact of Clinical and Genomic Factors on Real-World Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 4 Additional Real-World Time to Next Treatment Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 5 Ways Oral SERDs and Targeted Therapies Could Continue to Reshape ER+ Breast Cancer Management

2 experts in this video

EP. 6 Persisting Questions in ER+ Breast Cancer in the Second Line and Beyond

Hope S. Rugo, MD, and Seth Wander, MD, PhD, address key unanswered questions in the management of estrogen receptor–positive breast cancer beyond the first line of therapy. They discuss optimal sequencing, biomarker integration, and how to individualize treatment as new options emerge. Rugo and Wander conclude by emphasizing areas where additional research is needed to further improve patient outcomes.

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