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Opinion|Videos|January 16, 2026

The Impact of Clinical and Genomic Factors on Real-World Outcomes With Elacestrant in ESR1+ Breast Cancer

Author(s)Hope S. Rugo, MD, Seth Wander, MD, PhD

Explore the impact of elacestrant on ESR1-mutated breast cancer, revealing real-world data insights and genomic factors influencing treatment outcomes.

Episodes in this series

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

2 experts in this video

EP. 3 The Impact of Clinical and Genomic Factors on Real-World Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 4 Additional Real-World Time to Next Treatment Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 5 Ways Oral SERDs and Targeted Therapies Could Continue to Reshape ER+ Breast Cancer Management

2 experts in this video

EP. 6 Persisting Questions in ER+ Breast Cancer in the Second Line and Beyond

Hope S. Rugo, MD, and Seth Wander, MD, PhD, examine how clinical characteristics and genomic alterations influence real-world outcomes with elacestrant in ESR1-mutant breast cancer. They discuss correlations between mutation profiles, treatment response, and durability of benefit. Rugo and Wander highlight how these insights may refine patient selection in routine practice.

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Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

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Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

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