Opinion|Videos|January 16, 2026

The Impact of Clinical and Genomic Factors on Real-World Outcomes With Elacestrant in ESR1+ Breast Cancer

Explore the impact of elacestrant on ESR1-mutated breast cancer, revealing real-world data insights and genomic factors influencing treatment outcomes.

Hope S. Rugo, MD, and Seth Wander, MD, PhD, examine how clinical characteristics and genomic alterations influence real-world outcomes with elacestrant in ESR1-mutant breast cancer. They discuss correlations between mutation profiles, treatment response, and durability of benefit. Rugo and Wander highlight how these insights may refine patient selection in routine practice.


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