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Opinion|Videos|January 16, 2026

Ways Oral SERDs and Targeted Therapies Could Continue to Reshape ER+ Breast Cancer Management

Author(s)Hope S. Rugo, MD, Seth Wander, MD, PhD

Experts discuss the implications of the SERENA-6 trial, highlighting the potential benefits of early oral SERD deployment in breast cancer treatment.

Episodes in this series

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

2 experts in this video

EP. 3 The Impact of Clinical and Genomic Factors on Real-World Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 4 Additional Real-World Time to Next Treatment Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 5 Ways Oral SERDs and Targeted Therapies Could Continue to Reshape ER+ Breast Cancer Management

2 experts in this video

EP. 6 Persisting Questions in ER+ Breast Cancer in the Second Line and Beyond

Hope S. Rugo, MD, and Seth Wander, MD, PhD, discuss how oral SERDs and emerging targeted therapies may continue to reshape estrogen receptor–positive breast cancer management. They explore combination strategies and evolving mechanisms of resistance. Rugo and Wander consider how these advances may influence future standards of care.

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