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Opinion|Videos|January 16, 2026

Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

Author(s)Hope S. Rugo, MD, FASCO, Seth Wander, MD, PhD

Hope S. Rugo, MD, and Seth Wander, MD, PhD, discuss treatment selection after CDK4/6 inhibitor progression in advanced ER-positive breast cancer.

Episodes in this series

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 1 Treatment Selection Post–CDK4/6 Inhibition in Advanced ER+ Breast Cancer

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

EP. 2 The Role of Elacestrant in ER+/HER2– Advanced Breast Cancer Harboring ESR1 Mutations

2 experts in this video

EP. 3 The Impact of Clinical and Genomic Factors on Real-World Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 4 Additional Real-World Time to Next Treatment Outcomes With Elacestrant in ESR1+ Breast Cancer

2 experts in this video

EP. 5 Ways Oral SERDs and Targeted Therapies Could Continue to Reshape ER+ Breast Cancer Management

2 experts in this video

EP. 6 Persisting Questions in ER+ Breast Cancer in the Second Line and Beyond

Hope S. Rugo, MD, and Seth Wander, MD, PhD, discuss treatment selection strategies for patients with advanced estrogen receptor–positive breast cancer following progression on CDK4/6 inhibitors. They review how endocrine sensitivity, prior therapies, and molecular features influence next-line decision-making. Rugo and Wander also highlight the growing role of oral SERDs in combination with targeted agents.

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