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Opinion|Videos|October 18, 2024

Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

Author(s)Ajay Chari, MD, Noopur S. Raje, MD, Adriana Rossi, MD, Weill Cornell Medical College

Panelists discuss whether daratumumab quadruplet induction regimens should be considered the new standard of care for newly diagnosed transplant-eligible patients and explore scenarios in which a triplet induction regimen might still be appropriate. They also review the findings from the ISKIA and GMMG-CONCEPT trials, including considerations for using isatuximab-carfilzomib (IsaKRd) over D-VRd.

Episodes in this series

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

In your clinical opinion, are daratumumab quadruplet induction regimens the new standard of care for newly diagnosed (transplant-eligible) patients? Are there patients for whom you would still consider a triplet induction regimen?
Could you also review the ISKIA & GMMG-CONCEPT trials and findings? Are there any clinical scenarios where you would consider an isatuximab-carfilzomib (IsaKRd) quadruplet over D-VRd?

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