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Opinion|Videos|November 1, 2024

Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

Author(s)Ajay Chari, MD, Noopur S. Raje, MD, Adriana Rossi, MD, Weill Cornell Medical College

Panelists discuss the currently available chimeric antigen receptor T-cell therapies for early relapse multiple myeloma, examining their place within the treatment paradigm and how factors such as product type (cilta-cel vs ide-cel) and high-risk features (such as minimal residual disease positivity post induction and extramedullary disease) influence clinical decision-making.

Episodes in this series

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

Dr Ajai Chari to Dr Rossi: Can you please briefly review the currently available chimeric antigen receptor (CAR) T-cell therapies for early relapse multiple myeloma?
Dr Ajai Chari to Dr Rossi (then open to panelists): Where does CAR T-cell therapy currently fall in your treatment paradigm? Does it differ by product (cilta-cel vs ide-cel) or by high-risk features (minimal residual disease positivity post induction, extramedullary disease, etc)?

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