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Opinion|Videos|October 25, 2024

Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

Author(s)Ajay Chari, MD, Noopur S. Raje, MD, Adriana Rossi, MD, Weill Cornell Medical College

Panelists discuss the CEPHEUS trial results for newly diagnosed patients who are not transplant eligible, highlighting key takeaways. They also compare the CEPHEUS data with other quadruplet regimens in the non–transplant-eligible space, such as Isa-VRd.

Episodes in this series

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

Dr Ajai Chari to Dr Callander: Switching to those newly diagnosed patients who are not transplant eligible or for whom transplant is not planned as initial therapy, Dr Callander, can you summarize the CEPHEUS data results presented at IMS and your key takeaways from this trial?

Resource Links

OA-63 IMS 2024 CEPHEUS or (see page 11)

Dr Ajai Chari to Dr Martin: How do CEPHEUS data compare to other quadruplet regimens in the non–transplant-eligible space, like Isa-VRd?

Resource Link

OA-49 IMS 2024 IMROZ or (see page 12)
Facon T et al. IMROZ Isa-VRd vs. VRd. ASCO 2024 Abstract

Resource Link:

OA-52 IMS 2024 BENEFIT or (see page 13)
Leleu X, et al. BENEFIT trial Isa-VRd vs. IsaRd. Nat Med. 2024.

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