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Opinion|Videos|November 8, 2024

Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

Author(s)Ajay Chari, MD, Noopur S. Raje, MD, Adriana Rossi, MD, Weill Cornell Medical College

Panelists discuss how patient and disease factors influence the choice between ide-cel and cilta-cel for chimeric antigen receptor (CAR) T-cell therapy, the significance of adverse event profiles in clinical decision-making, the use of bridging therapy prior to infusion, and the experiences of progression rates and potential mechanisms post treatment, as well as future directions for CAR T-cell therapy in relapsed/refractory multiple myeloma.

Episodes in this series

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 1 Transplant Eligible, Newly Diagnosed Multiple Myeloma: PERSEUS & CASSIOPEIA Study Updates

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 2 Quadruplet Induction Regimen in Newly Diagnosed Multiple Myeloma

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 3 Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma: CEPHEUS, IMROZ, and BENEFIT Studies

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 4 MRD Negativity as a Trial Outcome and Its Use in Clinical Practice

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 5 Use of CAR T-cell Therapies for Early Relapse Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 6 Considerations for Triplet or Quadruplet Regimens in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 7 Considerations for Use of CAR T-cell Therapy in Multiple Myeloma

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 8 CAR T-cell Therapies for Multiple Myeloma: KarMMa-3 and CARTITUDE-4 Study Updates at IMS 2024

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 9 Insights from IMS 2024 on Counseling Patients with Multiple Myeloma about CAR T-cell Therapy and Connecting to Referral Centers

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

EP. 10 Importance of Early Referral for CAR T-cell Therapy in Multiple Myeloma and Patient Quality of Life

Dr Ajai Chari to Dr Rossi (then open to panelists): What patient or disease factors do you weigh when deciding whether a patient should receive ide-cel vs cilta-cel?
Dr Ajai Chari to Dr Martin: When weighing treatment options, how heavily is the chimeric antigen receptor (CAR) T adverse effect (AE) profile considered in your clinical judgment?

What are the similarities and differences between the AE profiles of ide-cel vs cilta-cel?

Dr Ajai Chari to Dr Callander: What is your approach to bridging therapy prior to CAR T-cells being infused?

How frequently do you utilize bridging therapy? What agents are you typically using?

Dr Ajai Chari to Dr Raje: Of the patients you have treated with CAR T-cell therapy, what percentage of patients have progressed?

How long until progression occurs in your experience?
What are some possible mechanisms of release post CAR T-cell therapy?

Dr Ajai Chari to Dr Rossi: What are some future directions for CAR T-cell therapy in relapsed/refractory multiple myeloma?

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