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Opinion|Videos|December 5, 2025

Role of Age and Ph Status in Blinatumomab Selection in ALL

Author(s)Jonathan Webster, MD, Nikesh Shah, MD

Jonathan Webster, MD, and Nikesh Shah, MD, discuss who age and Philadelphia chromosome status influence blinatumomab initiation in ALL.

Episodes in this series

EP. 1 How Blinatumomab Is Utilized in ALL Management

EP. 1 How Blinatumomab Is Utilized in ALL Management

EP. 2 Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

EP. 2 Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

EP. 3 Role of Age and Ph Status in Blinatumomab Selection in ALL

EP. 3 Role of Age and Ph Status in Blinatumomab Selection in ALL

EP. 4 Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

EP. 4 Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

EP. 5 Other Possible Research Avenues for Blinatumomab in ALL

EP. 5 Other Possible Research Avenues for Blinatumomab in ALL

EP. 6 Ongoing Research to Watch at ASH 2025 and Beyond

EP. 6 Ongoing Research to Watch at ASH 2025 and Beyond

Jonathan Webster, MD, and Nikesh Shah, MD, describe how patient age and Philadelphia chromosome (Ph) status influence the decision to incorporate blinatumomab (Blincyto) into an ALL treatment plan. They discuss how younger adults, older adults, and patients with Ph-positive or Ph-negative disease may derive different levels of benefit based on disease biology and treatment tolerance. They also outline how these factors guide personalized treatment algorithms and optimize therapeutic outcomes.

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