Opinion|Videos|December 5, 2025
Role of Age and Ph Status in Blinatumomab Selection in ALL
Author(s)Jonathan Webster, MD, Nikesh Shah, MD
Jonathan Webster, MD, and Nikesh Shah, MD, discuss who age and Philadelphia chromosome status influence blinatumomab initiation in ALL.
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Jonathan Webster, MD, and Nikesh Shah, MD, describe how patient age and Philadelphia chromosome (Ph) status influence the decision to incorporate blinatumomab (Blincyto) into an ALL treatment plan. They discuss how younger adults, older adults, and patients with Ph-positive or Ph-negative disease may derive different levels of benefit based on disease biology and treatment tolerance. They also outline how these factors guide personalized treatment algorithms and optimize therapeutic outcomes.
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