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Opinion|Videos|December 5, 2025

Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

Author(s)Jonathan Webster, MD, Nikesh Shah, MD

Jonathan Webster, MD, and Nikesh Shah, MD, discuss data for blinatumomab in younger adult patients with BCR:ABL1–negative B-ALL.

Episodes in this series

EP. 1 How Blinatumomab Is Utilized in ALL Management

EP. 1 How Blinatumomab Is Utilized in ALL Management

EP. 2 Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

EP. 2 Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

EP. 3 Role of Age and Ph Status in Blinatumomab Selection in ALL

EP. 3 Role of Age and Ph Status in Blinatumomab Selection in ALL

EP. 4 Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

EP. 4 Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

EP. 5 Other Possible Research Avenues for Blinatumomab in ALL

EP. 5 Other Possible Research Avenues for Blinatumomab in ALL

EP. 6 Ongoing Research to Watch at ASH 2025 and Beyond

EP. 6 Ongoing Research to Watch at ASH 2025 and Beyond

Jonathan Webster, MD, and Nikesh Shah, MD, review data on the clinical activity of blinatumomab in younger adults with BCR::ABL1–negative B-cell ALL, focusing on remission depth and survival outcomes. They highlight how early integration of blinatumomab can enhance MRD clearance and potentially reduce the need for more intensive therapies. Webster and Shah also discuss emerging evidence suggesting particularly meaningful benefit in this younger patient population.

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