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Opinion|Videos|November 26, 2025

Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

Author(s)Jonathan Webster, MD, Nikesh Shah, MD

Jonathan Webster, MD, and Nikesh Shah, MD, detail current treatment approaches in frontline acute lymphoblastic leukemia.

Episodes in this series

EP. 1 How Blinatumomab Is Utilized in ALL Management

EP. 1 How Blinatumomab Is Utilized in ALL Management

EP. 2 Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

EP. 2 Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

EP. 3 Role of Age and Ph Status in Blinatumomab Selection in ALL

EP. 3 Role of Age and Ph Status in Blinatumomab Selection in ALL

EP. 4 Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

EP. 4 Outcomes With Blinatumomab in Younger Adults With BCR:ABL1–negative B-ALL

EP. 5 Other Possible Research Avenues for Blinatumomab in ALL

EP. 5 Other Possible Research Avenues for Blinatumomab in ALL

EP. 6 Ongoing Research to Watch at ASH 2025 and Beyond

EP. 6 Ongoing Research to Watch at ASH 2025 and Beyond

Jonathan Webster, MD, and Nikesh Shah, MD, outline current frontline treatment strategies in acute lymphoblastic leukemia (ALL), emphasizing how risk stratification, molecular profiling, and patient fitness guide regimen selection. They highlight key distinctions between pediatric-inspired and adult-based approaches, noting how these paradigms continue to evolve with emerging clinical evidence. Webster and Shah also address persistent challenges in early disease management, including toxicity mitigation and optimal integration of immunotherapies.

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