Current Frontline Treatment Considerations in Acute Lymphoblastic Leukemia

Jonathan Webster, MD, and Nikesh Shah, MD, outline current frontline treatment strategies in acute lymphoblastic leukemia (ALL), emphasizing how risk stratification, molecular profiling, and patient fitness guide regimen selection. They highlight key distinctions between pediatric-inspired and adult-based approaches, noting how these paradigms continue to evolve with emerging clinical evidence. Webster and Shah also address persistent challenges in early disease management, including toxicity mitigation and optimal integration of immunotherapies.