Ariela Katz

Articles

An Explorer's Mentality Leads to Novel Treatments in Prostate and Bladder Cancer

December 10th 2018

Although he held a longtime fascination with space exploration to the moon and Mars, Daniel P. Petrylak, MD, took a different path and broke new ground in another frontier: genitourinary oncology.

San Diego Urology Group Enjoys Growth in a Tough Market

November 30th 2018

Genesis Healthcare Partners, the region’s largest independent urology practice, is challenged by regulatory changes and the dominance of the regional managed care market, which has huge control of patient flow and payment structures.

Triplet Therapy With Novel PD-1 Inhibitor Holds Promise in Melanoma

November 28th 2018

The addition of a novel PD-1 inhibitor to a combination of BRAF inhibitor dabrafenib (Tafinlar) and MEK inhibitor trametinib (Mekinist) is being tested to determine whether the triplet is safe and effective for patients with metastatic or unresectable melanoma.

Novel Oral Paclitaxel Formulation Aims to Overcome Drawbacks of IV Version

November 12th 2018

Investigators are assessing whether Oraxol, an oral formulation of paclitaxel, will be safer and more efficacious than the widely used chemotherapy drug administered by traditional intravenous infusion.

Starving Tumors of Important Amino Acid May Extend Survival in Pancreatic Cancer

October 8th 2018

Investigators are evaluating whether eryaspase (Graspa), an L-asparaginase-based therapy that triggers tumor cell death, can extend survival for patients with pancreatic cancer.

FDA Grants Rucaparib Breakthrough Designation for mCRPC

October 2nd 2018

The FDA has granted the PARP inhibitor rucaparib a breakthrough therapy designation for single-agent use in adult patients with BRCA1/2-positive metastatic castration-resistant prostate cancer following at least 1 androgen receptor–directed therapy and taxane-based chemotherapy.

Novel Agent Stimulates T-Cell Activity in Tumor Microenvironment

October 2nd 2018

Investigators are hopeful that M7824, a bifunctional fusion protein that inhibits the PD-L1 and TGF-β pathways, will improve immune system responses across tumor types.

Patient-Centered Focus Drives Growth at Virginia Urology

September 19th 2018

Virginia Urology, a practice with specialists in surgery, radiation, and oncology, has grown steadily over 75 years by remaining patient focused. Centered in Richmond, Virginia Urology has always prioritized quality care.

Testing for RET Alterations Gains Traction Across Tumor Types

August 30th 2018

In recent years, tyrosine kinase inhibitors that specifically target RET have entered the pipeline. Although none have yet received FDA approval, the promise of these agents has spurred interest in diagnostic assays.

Potency of CAR T-Cell Therapy Investigated in Relapsed/Refractory MCL

August 22nd 2018

Axicabtagene ciloleucel (axi-cel; Yescarta) is being evaluated in patients with relapsed or refractory mantle cell lymphoma—a rare B-cell non-Hodgkin lymphoma that contributes 4200 new patients in the United States each year.