Namrata (Neena) Vijayvergia, MD

Discover the future of cancer treatment with innovative therapies and groundbreaking research in radiopharmaceuticals and theranostics.

Experts discuss the promising future of CAR-T therapy and radioligand treatments for neuroendocrine tumors, highlighting new trials and potential breakthroughs.

Experts discuss the challenges of sequencing treatments like cabozantinib and managing side effects in patients with metastatic disease.

Dr. Chauhan discusses the groundbreaking CABINET trial, revealing its impact on treating neuroendocrine tumors and the future of oncology research.

Experts discuss treatment options for a young patient with pancreatic neuroendocrine tumor and liver metastases, focusing on targeted therapies.

Doctor Hendifer discusses the diverse therapies for neuroendocrine neoplasms, emphasizing individualized treatment based on patient needs and disease characteristics.

Experts discuss advanced treatment options for neuroendocrine tumors, highlighting PRRT, mTOR inhibitors, and emerging therapies for improved patient outcomes.

Oncology treatment decisions hinge on tumor biology and patient factors, emphasizing a multidisciplinary approach for optimal care.

Experts discuss treatment strategies for neuroendocrine tumors, emphasizing personalized approaches based on tumor grade, symptoms, and patient health.

Explore the complexities of treating neuroendocrine tumors, focusing on patient-specific strategies and the role of somatostatin analogs.

Experts discuss key factors influencing disease prognosis, emphasizing differentiation, growth pace, and disease burden in treatment decisions.

Experts discuss the evolution of neuroendocrine tumor classification, highlighting its clinical implications and the importance of standardized treatment approaches.

Experts discuss the evolution of neuroendocrine tumor classification, highlighting its impact on diagnosis, treatment, and clinical implications.

Imaging Modalities for Neuroendocrine Tumors

Classification of Neuroendocrine Tumors

Panelists discuss how the field of neuroendocrine tumors (NETs) is advancing with the emergence of new therapies, including alpha therapies, somatostatin receptor-targeting approaches, and research into high-grade NETs, while highlighting the importance of staying updated on evolving treatments to improve patient outcomes.

Panelists emphasized that managing cabozantinib treatment in NET patients requires a proactive, multidisciplinary approach, including dose adjustments, patient education, and close follow-up, to effectively manage adverse effects and ensure durable treatment.

Panelists discuss cabozantinib’s role in the neuroendocrine tumor treatment landscape, emphasizing its utility as a third-line option post somatostatin analogues and systemic therapy, while highlighting its efficacy in heavily pretreated patients, the importance of careful sequencing—especially relative to PRRT—and considerations for ideal patient selection, including those with grade 3 well-differentiated tumors.

Panelists discuss the CABINET trial’s safety findings, noting that while cabozantinib showed a manageable toxicity profile similar to other cancers, its use in heavily pretreated neuroendocrine tumor patients—especially post peptide receptor radionuclide therapy—requires careful dose management due to adverse effects like cytopenias and palmar-plantar erythrodysesthesia, prompting interest in alternative dosing strategies to improve tolerability

Panelists discuss the CABINET trial’s findings that cabozantinib significantly improved progression-free survival in both pancreatic and extrapancreatic neuroendocrine tumors, highlighting its efficacy in a heavily pretreated, real-world population and noting the trial’s inclusive design, crossover protocol, and implications for broader clinical use.

Panelists discuss the complexities of managing neuroendocrine tumors (NETs), highlighting challenges in patient communication, treatment sequencing, and systemic barriers related to drug approvals, while emphasizing the need for personalized care and broader access to versatile therapies like peptide receptor radionuclide therapy.

Panelists discuss the rationale and design of the CABINET trial evaluating cabozantinib in neuroendocrine tumors (NETs), emphasizing the drug’s multitargeted anti-angiogenic activity, the study’s credibility as a cooperative group-led effort, and the use of progression-free survival as an appropriate primary end point given the disease’s indolent nature and complex treatment landscape

Panelists discuss how management of advanced neuroendocrine tumors (NETs) has evolved with therapies like somatostatin analogues and peptide receptor radionuclide therapy, while emphasizing the importance of personalized treatment strategies and ongoing innovation in response to tumor progression and individual variability in outcomes.

Panelists discuss how neuroendocrine tumors (NETs), once considered rare, are increasingly recognized due to improved diagnostics and their complex, often delayed presentation, highlighting the importance of clinician awareness and the growing significance of NETs in oncology.

Namrata (Neena) Vijayvergia, MD, discusses the efficacy of pembrolizumab with or without chemotherapy in patients with microsatellite instability–high advanced gastric cancer.