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Opinion|Videos|December 23, 2025

CABINET Study and Cabozantinib for Treatment of NETS

Author(s)Namrata (Neena) Vijayvergia, MD, Junaid Arshad, MD, MS, Aman Chauhan, MD

Dr. Chauhan discusses the groundbreaking CABINET trial, revealing its impact on treating neuroendocrine tumors and the future of oncology research.

Episodes in this series

EP. 1 Classification of Neuroendocrine Tumors

EP. 1 Classification of Neuroendocrine Tumors

EP. 2 Imaging Modalities for Neuroendocrine Tumors

EP. 2 Imaging Modalities for Neuroendocrine Tumors

EP. 3 Early Diagnosis of Neuroendocrine Tumors

EP. 3 Early Diagnosis of Neuroendocrine Tumors

EP. 4 Role of Biomarkers in Diagnosis and Management of NETS

EP. 4 Role of Biomarkers in Diagnosis and Management of NETS

EP. 5 Prognostic Factors for Neuroendocrine Tumors

EP. 5 Prognostic Factors for Neuroendocrine Tumors

EP. 6 First-Line Treatment and Standard of Care for NETS

EP. 6 First-Line Treatment and Standard of Care for NETS

EP. 7 Site of Origin and Treatment of NETS

EP. 7 Site of Origin and Treatment of NETS

EP. 8 Inadequate Response and Second-Line Treatment of NETS

EP. 8 Inadequate Response and Second-Line Treatment of NETS

EP. 9 Sequencing of Systemic NETS Treatments

EP. 9 Sequencing of Systemic NETS Treatments

EP. 10 Treatment Options for High Grade (Grade 3) NETS

EP. 10 Treatment Options for High Grade (Grade 3) NETS

EP. 11 Patient with NETS Post PRRT in Second-Line

EP. 11 Patient with NETS Post PRRT in Second-Line

EP. 12 CABINET Study and Cabozantinib for Treatment of NETS

EP. 12 CABINET Study and Cabozantinib for Treatment of NETS

EP. 13 Sequencing and Place of Cabozantinib in NETS Treatment Algorithm

EP. 13 Sequencing and Place of Cabozantinib in NETS Treatment Algorithm

EP. 14 CAR-T and Radioligand Therapies for Treatment of NETS

EP. 14 CAR-T and Radioligand Therapies for Treatment of NETS

EP. 15 Theranostics and Management of NETS Going Forward

EP. 15 Theranostics and Management of NETS Going Forward

The specialists discussed emerging therapies for neuroendocrine tumors (NETs), focusing on the recent CABINET trial of cabozantinib, a VEGFR-targeted multi-kinase inhibitor. This phase III, randomized, double-blind, placebo-controlled study included both pancreatic and extra-pancreatic NETs, covering all well-differentiated grades (1–3) and including rare thoracic NETs. The trial demonstrated a signiﬁcant progression-free survival (PFS) beneﬁt across all subgroups, with cytoreductive activity (17–19% response rate) in pancreatic NETs, providing a new option for patients needing tumor reduction. The study was notable as a cooperative group effort, developed with community and patient advocacy input, emphasizing rigorous, ethical trial design and a crossover option from placebo. Thoracic NETs, often excluded from studies, also showed substantial beneﬁt (median PFS 8.2 vs. 2.7 months). The panel highlighted that PFS remains a meaningful endpoint in NETs, particularly for patients in diverse practice settings. They also noted ongoing trials, such as with zanzalintinib, exploring additional VEGFR-targeted therapies for broader NET populations.

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