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Opinion|Videos|January 14, 2026

Theranostics and Management of NETS Going Forward

Author(s)Namrata (Neena) Vijayvergia, MD, Junaid Arshad, MD, MS, Aman Chauhan, MD

Discover the future of cancer treatment with innovative therapies and groundbreaking research in radiopharmaceuticals and theranostics.

Episodes in this series

EP. 1 Classification of Neuroendocrine Tumors

EP. 1 Classification of Neuroendocrine Tumors

EP. 2 Imaging Modalities for Neuroendocrine Tumors

EP. 2 Imaging Modalities for Neuroendocrine Tumors

EP. 3 Early Diagnosis of Neuroendocrine Tumors

EP. 3 Early Diagnosis of Neuroendocrine Tumors

EP. 4 Role of Biomarkers in Diagnosis and Management of NETS

EP. 4 Role of Biomarkers in Diagnosis and Management of NETS

EP. 5 Prognostic Factors for Neuroendocrine Tumors

EP. 5 Prognostic Factors for Neuroendocrine Tumors

EP. 6 First-Line Treatment and Standard of Care for NETS

EP. 6 First-Line Treatment and Standard of Care for NETS

EP. 7 Site of Origin and Treatment of NETS

EP. 7 Site of Origin and Treatment of NETS

EP. 8 Inadequate Response and Second-Line Treatment of NETS

EP. 8 Inadequate Response and Second-Line Treatment of NETS

EP. 9 Sequencing of Systemic NETS Treatments

EP. 9 Sequencing of Systemic NETS Treatments

EP. 10 Treatment Options for High Grade (Grade 3) NETS

EP. 10 Treatment Options for High Grade (Grade 3) NETS

EP. 11 Patient with NETS Post PRRT in Second-Line

EP. 11 Patient with NETS Post PRRT in Second-Line

EP. 12 CABINET Study and Cabozantinib for Treatment of NETS

EP. 12 CABINET Study and Cabozantinib for Treatment of NETS

EP. 13 Sequencing and Place of Cabozantinib in NETS Treatment Algorithm

EP. 13 Sequencing and Place of Cabozantinib in NETS Treatment Algorithm

EP. 14 CAR-T and Radioligand Therapies for Treatment of NETS

EP. 14 CAR-T and Radioligand Therapies for Treatment of NETS

EP. 15 Theranostics and Management of NETS Going Forward

EP. 15 Theranostics and Management of NETS Going Forward

Neuroendocrine tumor (NET) specialists discussed the exciting future of theranostics and radiopharmaceuticals in NET management and beyond. Dr. Chauhan highlighted that NETs have historically led advances in the ﬁeld, with Lutetium-177–based PRRT demonstrating high efficacy. The next generation includes alpha-emitting PRRT, offering higher-energy, double-stranded DNA breaks and promising early results with improved progression-free survival. Novel combinations with DNA damage repair inhibitors are also under investigation. Dr. Shaheen and colleagues emphasized emerging strategies including non-peptide drug conjugates targeting somatostatin receptors, DLL1-directed antibody-drug conjugates, and combination approaches like PD-1 inhibitors plus PRRT. Additionally, next-generation TKIs such as super Cabozantinib (zanzalintinib) show reduced toxicity while maintaining efficacy. Overall, specialists agreed that the next 12–24 months will be transformative, with over 100 theranostic agents in development across multiple solid tumors. These innovations promise enhanced tumor control, reduced side effects, and broader applicability, marking a pivotal moment for NET care and oncology therapeutics more broadly.

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Ana C. Garrido-Castro, MD; Pedram Razavi, MD, PhD

Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Tiffany A. Traina, MD, FASCO

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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