Silas Inman, Senior Vice President, Content, joined MJH Life Sciences™ in early 2011 as one of the company's first web editors. In this position, he built OncLive.com from a fledgling web platform to a leading source of oncology news for community oncologists via in-depth reporting of breaking news from major medical conferences and the launch of OncLive® TV.
Throughout his tenure at MJH, Silas has been accountable for several organic launches of highly successful brands, including Targeted Oncology™ and NeurologyLive®, and for quickly transforming acquisitions into high-functioning business units. Prior to joining MJH, Silas, who attended Eastern Michigan University, was an EMT, frontend web developer, and social media/SEO expert. Follow him on Twitter @SilasInman or email him at sinman@mjhlifesciences.com
Fewer CNS Metastases, Similar Efficacy Seen With Neratinib Versus Trastuzumab
November 14th 2014Frontline treatment with neratinib in combination with paclitaxel demonstrated similar ORR and PFS as the combination of trastuzumab and paclitaxel while lowering the incidence of CNS metastases in patients with locally recurrent or metastatic HER2-positive breast cancer.
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Bayer Restores Access to Radium-223 for Prostate Cancer
November 6th 2014Access to radium-223 dichloride has been restored following a temporary suspension in production by its manufacturer Bayer HealthCare Pharmaceuticals to adjust its manufacturing process to meet certain quality standards that the company has in place.
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ODAC Votes Against Panobinostat in Multiple Myeloma
November 6th 2014In what was described as a very difficult decision, ODAC voted 5-2 against the accelerated approval of the HDAC inhibitor panobinostat in combination with bortezomib and dexamethasone as a treatment for patients with multiple myeloma who have received at least one prior therapy.
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Adding GM-CSF to Ipilimumab Improves OS, Lowers Toxicity in Advanced Melanoma
November 5th 2014The addition of the GM-CSF agent sargramostim to the CTLA-4 inhibitor ipilimumab (Yervoy) prolonged overall survival (OS) and lowered toxicity for patients with unresectable stage III or IV melanoma
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Trebananib Misses Survival Goal in Phase III Ovarian Cancer Study
November 4th 2014The combination of paclitaxel and the angiogenesis inhibitor trebananib did not demonstrate a statistically significant improvement in overall survival when compared with paclitaxel alone for patients with recurrent platinum-resistant ovarian cancer.
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Fast Track Designation Granted to TAS-102 in mCRC
October 20th 2014The FDA has granted a fast track designation to TAS-102 (tipiracil hydrochloride) as a treatment for patients with refractory metastatic colorectal cancer (mCRC), according to an announcement by Taiho Oncology, the company developing the drug in the United States.
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Lenvatinib Receives Priority Review for RAI-Refractory DTC
October 17th 2014The FDA has granted a priority review to the oral multiple tyrosine kinase receptor inhibitor lenvatinib as a treatment for patients with progressive, radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC), according to the manufacturer of the drug, Eisai.
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ASCO Endorses Molecular Testing Guideline for Lung Cancer
October 14th 2014ASCO has endorsed the CAP/IASLC/AMP guideline on molecular testing for patients with lung cancer, which recommends EGFR and ALK testing for all patients with lung adenocarcinoma or mixed histology with an adenocarcinoma component.
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FDA Schedules ODAC Hearing for Panobinostat in Multiple Myeloma
October 9th 2014The FDA has scheduled an ODAC advisory hearing to discuss the new drug application for panobinostat in combination with bortezomib and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.
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Collaboration Joins Nivolumab With Targeted Therapies in NSCLC
October 7th 2014A clinical trial collaboration between Novartis and BMS has resulted in the establishment of several novel combination trials involving the PD-1 inhibitor nivolumab and targeted therapies against ALK, c-MET, and T790M for patients with NSCLC.
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FDA Grants Breakthrough Therapy Designation to AP26113 in NSCLC
October 2nd 2014The highly selective ALK inhibitor AP26113 has been granted a Breakthrough Therapy Designation by the FDA for the treatment of patients with ALK-positive metastatic NSCLC who received prior treatment with crizotinib.
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New Data Provide Insight Into Optimal Pre-Chemo Treatments for mCRPC
September 30th 2014The combination of abiraterone acetate and prednisone has demonstrated a statistically significant improvement in overall survival (OS) for men with metastatic castration-resistant prostate cancer (mCRPC) who had not received prior treatment with chemotherapy
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Crizotinib Highly-Effective in ROS1-Rearranged NSCLC
September 29th 2014Treatment with crizotinib (Xalkori) demonstrated an overall response rate (ORR) of 72% in patients with ROS1-rearranged non–small cell lung cancer (NSCLC), according to phase I data presented at the 2014 ESMO Congress and published in The New England Journal of Medicine.
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Amgen Seeks FDA Approval for Blinatumomab in ALL
September 22nd 2014A Biologics License Application has been submitted to the FDA for the bispecific T-cell engager (BiTE) antibody blinatumomab as a treatment for adult patients with Philadelphia-negative (Ph-) relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL)
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Blood-Based Biomarkers Predict Outcomes Following Neoadjuvant Treatment in Esophageal Cancer
September 16th 2014High pretreatment levels of serum VEGF-A and TGF-β1 indicated significantly worse disease-free survival (DFS) following neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma.
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