Vol. 21/No. 2 | OncologyLive

Targeting the Hedgehog Pathway Holds Promises and Pitfalls

January 18, 2020

Although small molecule inhibitors of the Hedgehog signaling pathway have transformed the treatment paradigm for advanced basal cell carcinoma, the most common form of skin cancer, efforts to expand their use to other tumor types have proved elusive.

Studies of Harassment in Oncologic Gynecology Add Fuel to Reform Efforts

January 18, 2020

Anecdotes of gender inequality and sexual harassment abound among gynecologic oncologists, but until recently, there had been no study to measure the problem in this profession. Findings reported in June 2019 suggesting that high numbers of men and women in this field were subject to sexual harassment were no surprise to investigators. Instead, they have strengthened national gender discrimination and sexual harassment reform efforts in oncologic gynecology.

Investigators Test Breakthrough-Designated Triplet in First-Line CRC

January 17, 2020

Investigators hope to answer a potentially paradigm-changing question in the phase II ANCHOR-CRC study (NCT03693170) of BRAF V600E–mutant colorectal cancer (CRC): Can the benefit observed with a targeted triplet in latestage disease extend to the first line?

Molecular Testing for Colon Cancer Falls Far Short of the Guidelines

January 16, 2020

Between 2013 and 2017, just 40% of patients with metastatic colon cancer received guideline-recommended biomarker testing that could have improved treatment decisions, according to findings from a retrospective study. Results also showed that adherence to evidence-based recommendations for genotyping was poor in academic and community settings alike.

PARP Inhibitors Gain Importance in Ovarian Cancer Lineup

January 15, 2020

PARP inhibitors are poised to acquire a stronger foothold in the frontline setting for advanced ovarian cancer, for which chemotherapy remains the backbone of treatment, according to a panel of gynecologic oncology experts who discussed the issue during an OncLive Peer Exchange® held during the European Society for Medical Oncology Congress 2019.

Patient Input Should Inform Oncology Trial Design and Interpretation

January 13, 2020

Even the most basic investigation into fundamental mechanisms of the development and progression of cancer in an in vitro system may generate data that, ultimately, prove vital to developing new approaches to prevent, diagnose, and treat malignant disease.