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Opinion|Videos|January 7, 2025

Academic Perspectives in Front-Line Treatment Goals in Newly Diagnosed Transplant-Ineligible Multiple Myeloma

Panelists discuss how patient selection for quadruplet therapy in transplant-ineligible/deferred NDMM requires careful consideration of multiple factors, including fitness level and comorbidities, while highlighting daratumumab-VRd’s potential advantages such as subcutaneous administration and demonstrated efficacy in the CEPHEUS trial despite increased complexity and cost considerations.

Episodes in this series

4 experts are featured in this series.

EP. 1 Emerging Updates in Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma: Discussion of the CEPHEUS Trial.

4 experts are featured in this series.

EP. 2 Quadruplet Regimens as Front-Line Therapy for Newly Diagnosed Transplant-Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 3 Academic Perspectives in Front-Line Treatment Goals in Newly Diagnosed Transplant-Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 4 Future Considerations for Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 5 CAR T and Evolving Treatment Paradigms for Early R/R MM

4 experts are featured in this series.

EP. 6 Expert Perspectives: Referrals and Present Challenges with CAR T for Early R/R MM

4 experts are featured in this series.

EP. 7 Optimal Strategies for Bridging Therapy for Patients Receiving CAR T in Early R/R MM

4 experts are featured in this series.

EP. 8 Cilta-Cel in Early R/R MM: Evolving CAR T Data from CARTITUDE-4

4 experts are featured in this series.

EP. 9 CAR T in Early R/R MM: Advances in Ide-Cel From the KarMMa-3 Trial

4 experts are featured in this series.

EP. 10 Weighing CAR T Toxicity Profiles in Early R/R MM

4 experts are featured in this series.

EP. 11 The Evolving Landscape: CAR T and Future Therapies in Early-Stage R/R Myeloma

4 experts are featured in this series.

EP. 12 Treatment Overview in Later-Stage Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 13 Recent Insights Into Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 14 Novel Bispecific Antibodies in Development for Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 15 Future Treatment Considerations for Multiple Myeloma

Video content above is prompted by the following:

How do you determine which patients are best suited for quadruplet therapy?
What outcomes and factors are critical to consider?
MRD negativity? Depth of response? Safety? Relapse? Other?
Share perspectives on how the Dara-VRd regimen from CEPHEUS could impact the treatment landscape for TIE or deferred NDMM.
What advantages (ie, SC administration) does the regimen provide?
What other benefits or challenges should be considered?

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