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Opinion|Videos|February 11, 2025

Weighing CAR T Toxicity Profiles in Early R/R MM

Panelists discuss how recent data from the KarMMa-3 study influence the decision to treat early-stage relapsed/refractory multiple myeloma (R/R MM) with idecabtagene vicleucel (ide-cel), as well as the key toxicities considered when selecting chimeric antigen receptor (CAR) T-cell therapy. They also explore how these toxicities impact the transition of patients back to the community setting post CAR T and share strategies for managing early- and late-stage toxicities.

Episodes in this series

4 experts are featured in this series.

EP. 1 Emerging Updates in Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma: Discussion of the CEPHEUS Trial.

4 experts are featured in this series.

EP. 2 Quadruplet Regimens as Front-Line Therapy for Newly Diagnosed Transplant-Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 3 Academic Perspectives in Front-Line Treatment Goals in Newly Diagnosed Transplant-Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 4 Future Considerations for Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 5 CAR T and Evolving Treatment Paradigms for Early R/R MM

4 experts are featured in this series.

EP. 6 Expert Perspectives: Referrals and Present Challenges with CAR T for Early R/R MM

4 experts are featured in this series.

EP. 7 Optimal Strategies for Bridging Therapy for Patients Receiving CAR T in Early R/R MM

4 experts are featured in this series.

EP. 8 Cilta-Cel in Early R/R MM: Evolving CAR T Data from CARTITUDE-4

4 experts are featured in this series.

EP. 9 CAR T in Early R/R MM: Advances in Ide-Cel From the KarMMa-3 Trial

4 experts are featured in this series.

EP. 10 Weighing CAR T Toxicity Profiles in Early R/R MM

4 experts are featured in this series.

EP. 11 The Evolving Landscape: CAR T and Future Therapies in Early-Stage R/R Myeloma

4 experts are featured in this series.

EP. 12 Treatment Overview in Later-Stage Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 13 Recent Insights Into Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 14 Novel Bispecific Antibodies in Development for Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 15 Future Treatment Considerations for Multiple Myeloma

Video content above is prompted by the following:

Dr Rodriguez to Dr Neparidze: What toxicities do you weigh most when deciding which CAR T to use for early R/R MM?
Dr Rodriguez to faculty: Post CAR T, how do those toxicities impact when you transition your patients back to the community setting?
Dr Rodriguez to faculty: What strategies would you advise for managing and mitigating early- vs late-stage toxicities?

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