Opinion|Videos|February 11, 2025
Weighing CAR T Toxicity Profiles in Early R/R MM
Panelists discuss how recent data from the KarMMa-3 study influence the decision to treat early-stage relapsed/refractory multiple myeloma (R/R MM) with idecabtagene vicleucel (ide-cel), as well as the key toxicities considered when selecting chimeric antigen receptor (CAR) T-cell therapy. They also explore how these toxicities impact the transition of patients back to the community setting post CAR T and share strategies for managing early- and late-stage toxicities.
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Episodes in this series
Video content above is prompted by the following:
- Dr Rodriguez to Dr Neparidze: What toxicities do you weigh most when deciding which CAR T to use for early R/R MM?
- Dr Rodriguez to faculty: Post CAR T, how do those toxicities impact when you transition your patients back to the community setting?
- Dr Rodriguez to faculty: What strategies would you advise for managing and mitigating early- vs late-stage toxicities?
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Did you catch all of this week's top oncology news? Test your knowledge with OncLive's Weekly News Quiz.
The FDA received a BLA for etentamig in relapsed/refractory multiple myeloma, based on response and PFS gains in the phase 3 CERVINO trial.
Elranatamab improved PFS vs 3 standard regimens in relapsed/refractory multiple myeloma in the phase 3 MagnetisMM-32 trial.
The FDA approved dostarlimab in rectal cancer and pembrolizumab in tumors with high mutational burden, Europe cleared teclistamab in myeloma, and more.
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