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Opinion|Videos|December 24, 2024

Emerging Updates in Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma: Discussion of the CEPHEUS Trial.

Panelists discuss how current treatment approaches for transplant-ineligible newly diagnosed multiple myeloma patients are evolving with the addition of anti-CD38 therapies to standard VRd backbone, while examining unmet needs and the role of MRD negativity as an endpoint through recent trial data including CEPHEUS.

Episodes in this series

4 experts are featured in this series.

EP. 1 Emerging Updates in Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma: Discussion of the CEPHEUS Trial.

4 experts are featured in this series.

EP. 2 Quadruplet Regimens as Front-Line Therapy for Newly Diagnosed Transplant-Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 3 Academic Perspectives in Front-Line Treatment Goals in Newly Diagnosed Transplant-Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 4 Future Considerations for Front-line Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma

4 experts are featured in this series.

EP. 5 CAR T and Evolving Treatment Paradigms for Early R/R MM

4 experts are featured in this series.

EP. 6 Expert Perspectives: Referrals and Present Challenges with CAR T for Early R/R MM

4 experts are featured in this series.

EP. 7 Optimal Strategies for Bridging Therapy for Patients Receiving CAR T in Early R/R MM

4 experts are featured in this series.

EP. 8 Cilta-Cel in Early R/R MM: Evolving CAR T Data from CARTITUDE-4

4 experts are featured in this series.

EP. 9 CAR T in Early R/R MM: Advances in Ide-Cel From the KarMMa-3 Trial

4 experts are featured in this series.

EP. 10 Weighing CAR T Toxicity Profiles in Early R/R MM

4 experts are featured in this series.

EP. 11 The Evolving Landscape: CAR T and Future Therapies in Early-Stage R/R Myeloma

4 experts are featured in this series.

EP. 12 Treatment Overview in Later-Stage Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 13 Recent Insights Into Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 14 Novel Bispecific Antibodies in Development for Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 15 Future Treatment Considerations for Multiple Myeloma

Video content above is prompted by the following:

To start, please provide a brief overview of treatment regimens for NDMM cases that are TIE or deferred per NCCN guidelines.
What are current unmet needs in the space?
How does the addition of an anti-CD38to bortezomib (V)/lenalidomide (R)/dexamethasone (d)impact outcomes in TIE or deferred NDMM?
What are key takeaways from CEPHEUS (DaraVRd vs VRd)
What are your thoughts on MRD negativity as a primary endpoint?

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