Opinion|Videos|February 25, 2025
Recent Insights Into Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma
Panelists comment on recent updates from the International Myeloma Society/ American Society of Hematology (IMS/ASH) 2024 annual meetings, discussing the efficacy of approved bispecific antibodies in relapsed/refractory multiple myeloma (R/R MM), including teclistamab (MajesTEC-1), elranatamab (MagnetisMM-3), and talquetamab (MonumenTAL-1).
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Video content above is prompted by the following:
- Briefly comment on recent updates from IMS/ASH 2024. In terms of efficacy, how do these approved bispecific antibodies perform?
- MajesTEC-1, Teclistamab in R/R MM
- MagnetisMM-3, Elranatamab in R/R MM
- MonumenTAL-1, Talquetamab in R/R MM
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The FDA received a BLA for etentamig in relapsed/refractory multiple myeloma, based on response and PFS gains in the phase 3 CERVINO trial.
Elranatamab improved PFS vs 3 standard regimens in relapsed/refractory multiple myeloma in the phase 3 MagnetisMM-32 trial.
The FDA approved dostarlimab in rectal cancer and pembrolizumab in tumors with high mutational burden, Europe cleared teclistamab in myeloma, and more.
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