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Opinion|Videos|January 19, 2026

Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

Author(s)Lindsay Rein, MD, Frederick Lansigan, MD

Lindsay Rein, MD, and Frederick Lansigan, MD, discuss additional findings from the SUMMIT trial from ASH 2025 for bezuclastinib in non-advanced systemic mastocytosis.

Episodes in this series

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 4 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 4 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 6 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 6 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

Lindsay Rein, MD, and Frederick Lansigan, MD, discuss additional SUMMIT trial data presented at ASH 2025, expanding on the clinical activity of bezuclastinib (CGT9486) in non-advanced systemic mastocytosis. They examine durability of response, patient-reported outcomes, and longer-term safety observations. Rein and Lansigan consider how these results further clarify the potential role of bezuclastinib in disease management.

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