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Opinion|Videos|December 22, 2025

Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

Author(s)Lindsay Rein, MD, Frederick Lansigan, MD

Lindsay Rein, MD, and Frederick Lansigan, MD, delve into the frequency of KIT D816V mutations in non-advanced systemic mastocytosis.

Episodes in this series

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 4 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 4 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 6 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 6 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

Lindsay Rein, MD, and Frederick Lansigan, MD, explore the prevalence and clinical significance of KIT D816V mutations in non-advanced systemic mastocytosis. They explain how mutation status influences diagnosis, prognostication, and emerging treatment strategies. Rein and Lansigan also discuss testing considerations and how molecular insights are reshaping disease characterization.

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