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Opinion|Videos|January 5, 2026

Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

Author(s)Lindsay Rein, MD, Frederick Lansigan, MD

Lindsay Rein, MD, and Frederick Lansigan, MD, detail other key data from ASH 2025 for non-advanced systemic mastocytosis and ongoing research to watch in the space.

Episodes in this series

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 4 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 4 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 5 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 6 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 6 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

Lindsay Rein, MD, and Frederick Lansigan, MD, highlight other notable data in non-advanced systemic mastocytosis presented at the 2025 ASH Annual Meeting and Exposition. They discuss emerging therapies, ongoing clinical trials, and areas of active investigation aimed at improving symptom control and quality of life. Rein and Lansigan conclude by emphasizing future research directions and closing the program with final reflections on progress in the field.

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