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Opinion|Videos|December 22, 2025

Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

Author(s)Lindsay Rein, MD, Frederick Lansigan, MD

Lindsay Rein, MD, and Frederick Lansigan, MD, discuss current treatment standards for non-advanced systemic mastocytosis.

Episodes in this series

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 4 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 4 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 5 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 6 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 6 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

Lindsay Rein, MD, and Frederick Lansigan, MD, review current treatment strategies for patients with non-advanced systemic mastocytosis, focusing on symptom-directed management and disease burden assessment. They discuss how antihistamines, mast cell–stabilizing agents, and supportive therapies remain foundational in clinical practice. Rein and Lansigan also highlight unmet needs that have driven interest in targeted therapies for this patient population.

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