Opinion|Videos|December 29, 2025
Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis
Author(s)Lindsay Rein, MD, Frederick Lansigan, MD
Lindsay Rein, MD, and Frederick Lansigan, MD, compare the profiles of the investigational agent bezuclastinib and the approved agent avapritinib in non-advanced systemic mastocytosis.
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Lindsay Rein, MD, and Frederick Lansigan, MD, compare the mechanisms of action and pharmacologic profiles of the investigational agent bezuclastinib (CGT9486) and the previously-approved therapy avapritinib (Ayvakit) in non-advanced systemic mastocytosis. They discuss differences in kinase selectivity, potency, and potential clinical implications. Rein and Lansigan provide context on how these distinctions may translate into efficacy and tolerability considerations.
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