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Opinion|Videos|January 12, 2026

SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

Author(s)Lindsay Rein, MD, Frederick Lansigan, MD

Lindsay Rein, MD, and Frederick Lansigan, MD, discuss data from the SUMMIT trial for bezuclastinib in non-advanced systemic mastocytosis.

Episodes in this series

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 1 Current Treatment Strategies for Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 2 Prevalence of KIT D816V Mutations in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 3 Comparing Mechanisms of Action for Bezuclastinib and Avapritinib in Non-Advanced Systemic Mastocytosis

EP. 4 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 4 SUMMIT Trial: Key Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 5 Additional SUMMIT Data for Bezuclastinib in Non-Advanced Systemic Mastocytosis

EP. 6 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

EP. 6 Other Key Updates and Ongoing Research in Non-Advanced Systemic Mastocytosis From ASH 2025

Lindsay Rein, MD, and Frederick Lansigan, MD, review key efficacy and safety data from the SUMMIT trial evaluating bezuclastinib (CGT9486) in patients with non-advanced systemic mastocytosis. They highlight improvements in symptom burden, mast cell activity, and relevant clinical endpoints. Rein and Lansigan discuss how these findings contribute to the growing evidence base supporting targeted KIT inhibition.

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