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Opinion|Videos|April 7, 2025

Amivantamab Toxicity Mitigation Strategies in the Treatment of EGFR-Mutant NSCLC

Author(s)Julia Rotow, MD, Edgardo S. Santos Castillero, MD, FACP, FASCO

Panelists discuss how various strategies have been developed to enhance the tolerability of intravenous amivantamab, including premedication, step-up dosing, and infusion rate adjustments. Adoption into clinical practice varies, with many institutions integrating these approaches to mitigate infusion-related reactions and improve patient outcomes.

Episodes in this series

2 experts in this video

EP. 1 Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

2 experts in this video

EP. 2 EGFR-Mutated NSCLC Disease Risk Stratification

2 experts in this video

EP. 3 Approaches to Patient Shared Decision-Making in EGFR-Mutated NSCLC

2 experts in this video

EP. 4 Maximizing Time on Therapy to Preserve Future Treatment Options in EGFR-Mutated NSCLC

2 experts in this video

EP. 5 Expert Thoughts on Continuing Osimertinib Therapy Beyond First Disease Progression in EGFR-Mutant NSCLC

2 experts in this video

EP. 6 Treatment Sequencing in the Second Line and Beyond in EGFR-Mutant NSCLC

2 experts in this video

EP. 7 Amivantamab Toxicity Mitigation Strategies in the Treatment of EGFR-Mutant NSCLC

2 experts in this video

EP. 8 Future Treatment Options in EGFR-Mutant NSCLC

Video content above is prompted by the following:

Various strategies have been developed to increase the tolerability of intravenous amivantamab. Have these strategies been adopted into your practice, and do you have any clinical pearls to share with our audience?

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