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Opinion|Videos|March 17, 2025

Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

Author(s)Julia Rotow, MD, Edgardo S. Santos Castillero, MD, FACP, FASCO

Panelists discuss how, when discussing frontline regimens for EGFR-mutated non–small cell lung cancer (NSCLC), the NCCN-recommended options include osimertinib monotherapy for its targeted approach with lower toxicity; amivantamab/lazertinib combination for potentially deeper responses in specific mutations; and osimertinib with platinum-doublet chemotherapy for more aggressive disease requiring enhanced tumor control.

Episodes in this series

2 experts in this video

EP. 1 Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

2 experts in this video

EP. 2 EGFR-Mutated NSCLC Disease Risk Stratification

2 experts in this video

EP. 3 Approaches to Patient Shared Decision-Making in EGFR-Mutated NSCLC

2 experts in this video

EP. 4 Maximizing Time on Therapy to Preserve Future Treatment Options in EGFR-Mutated NSCLC

2 experts in this video

EP. 5 Expert Thoughts on Continuing Osimertinib Therapy Beyond First Disease Progression in EGFR-Mutant NSCLC

2 experts in this video

EP. 6 Treatment Sequencing in the Second Line and Beyond in EGFR-Mutant NSCLC

2 experts in this video

EP. 7 Amivantamab Toxicity Mitigation Strategies in the Treatment of EGFR-Mutant NSCLC

2 experts in this video

EP. 8 Future Treatment Options in EGFR-Mutant NSCLC

Video content above is prompted by the following:

When discussing initial treatment options, how do you present the 3 recommended NCCN frontline regimens to patients: osimertinib monotherapy, amivantamab with lazertinib, and osimertinib combined with a platinum-containing doublet?

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