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Opinion|Videos|March 31, 2025

Expert Thoughts on Continuing Osimertinib Therapy Beyond First Disease Progression in EGFR-Mutant NSCLC

Author(s)Julia Rotow, MD, Edgardo S. Santos Castillero, MD, FACP, FASCO

Panelists discuss how medical professionals consider continuing osimertinib with second-line and subsequent therapies based on disease progression, resistance mechanisms, and patient response. It may be combined with other agents or switched depending on clinical trials, biomarkers, and overall treatment goals to optimize outcomes.

Episodes in this series

2 experts in this video

EP. 1 Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

2 experts in this video

EP. 2 EGFR-Mutated NSCLC Disease Risk Stratification

2 experts in this video

EP. 3 Approaches to Patient Shared Decision-Making in EGFR-Mutated NSCLC

2 experts in this video

EP. 4 Maximizing Time on Therapy to Preserve Future Treatment Options in EGFR-Mutated NSCLC

2 experts in this video

EP. 5 Expert Thoughts on Continuing Osimertinib Therapy Beyond First Disease Progression in EGFR-Mutant NSCLC

2 experts in this video

EP. 6 Treatment Sequencing in the Second Line and Beyond in EGFR-Mutant NSCLC

2 experts in this video

EP. 7 Amivantamab Toxicity Mitigation Strategies in the Treatment of EGFR-Mutant NSCLC

2 experts in this video

EP. 8 Future Treatment Options in EGFR-Mutant NSCLC

Video content above is prompted by the following:

What are your thoughts on continuing osimertinib treatment with second-line and subsequent therapies?

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