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Opinion|Videos|April 7, 2025

Future Treatment Options in EGFR-Mutant NSCLC

Author(s)Julia Rotow, MD, Edgardo S. Santos Castillero, MD, FACP, FASCO

Panelists discuss how emerging therapies like patritumab (a HER3-directed antibody-drug conjugate [ADC]), datopotamab (a TROP2 ADC), and ivonescimab (a PD-1/VEGF bispecific) show distinct toxicity profiles compared with existing treatments, potentially influencing earlier use. Balancing efficacy gains against toxicity risks remains critical in optimizing EGFR-mutated non–small cell lung cancer (NSCLC) treatment.

Episodes in this series

2 experts in this video

EP. 1 Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

2 experts in this video

EP. 2 EGFR-Mutated NSCLC Disease Risk Stratification

2 experts in this video

EP. 3 Approaches to Patient Shared Decision-Making in EGFR-Mutated NSCLC

2 experts in this video

EP. 4 Maximizing Time on Therapy to Preserve Future Treatment Options in EGFR-Mutated NSCLC

2 experts in this video

EP. 5 Expert Thoughts on Continuing Osimertinib Therapy Beyond First Disease Progression in EGFR-Mutant NSCLC

2 experts in this video

EP. 6 Treatment Sequencing in the Second Line and Beyond in EGFR-Mutant NSCLC

2 experts in this video

EP. 7 Amivantamab Toxicity Mitigation Strategies in the Treatment of EGFR-Mutant NSCLC

2 experts in this video

EP. 8 Future Treatment Options in EGFR-Mutant NSCLC

Video content above is prompted by the following:

There are several medications in the late stages of development, including the HER3-targeted ADC, patritumab, the TROP2 datopotamab, and the bispecific antibody ivonescimab, which targets both PD-1 and VEGF. How do their toxicity profiles differ from existing therapies, and do you anticipate them being used earlier in therapy?
Recently approved treatment options in EGFR-mutated NSCLC have modestly improved progression-free survival but are associated with high toxicity rates. As new treatments continue to be introduced, how do you weigh the potential increased efficacy against the risk of increased toxicity?

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