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Opinion|Videos|March 17, 2025

EGFR-Mutated NSCLC Disease Risk Stratification

Author(s)Julia Rotow, MD, Edgardo S. Santos Castillero, MD, FACP, FASCO

Panelists discuss how disease-related factors like central nervous system (CNS) involvement or specific metastatic sites can guide treatment selection, favoring agents with CNS penetration or targeted efficacy. Mutational factors, such as TP53 comutations, may impact therapy response. Patient-related aspects, including age and comorbidities, influence tolerability and regimen choice.

Episodes in this series

2 experts in this video

EP. 1 Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

2 experts in this video

EP. 2 EGFR-Mutated NSCLC Disease Risk Stratification

2 experts in this video

EP. 3 Approaches to Patient Shared Decision-Making in EGFR-Mutated NSCLC

2 experts in this video

EP. 4 Maximizing Time on Therapy to Preserve Future Treatment Options in EGFR-Mutated NSCLC

2 experts in this video

EP. 5 Expert Thoughts on Continuing Osimertinib Therapy Beyond First Disease Progression in EGFR-Mutant NSCLC

2 experts in this video

EP. 6 Treatment Sequencing in the Second Line and Beyond in EGFR-Mutant NSCLC

2 experts in this video

EP. 7 Amivantamab Toxicity Mitigation Strategies in the Treatment of EGFR-Mutant NSCLC

2 experts in this video

EP. 8 Future Treatment Options in EGFR-Mutant NSCLC

Video content above is prompted by the following:

In your expertise, which disease-related factors, such as CNS involvement or site of metastases, might suggest a preference for one treatment over the others?
What about mutational factors—for example, a TP53 comutation? Additionally, how do patient-related factors such as age and comorbidities influence your choice?

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