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Opinion|Videos|March 12, 2025

An Expert Insights on Recent Advancements in LS-SCLC

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how the ADRIATIC regimen integrates immunotherapy post-chemoradiation in late-stage small cell lung cancer (LS-SCLC). In patients with paraneoplastic syndromes or immune disorders, immunotherapy requires caution. Prophylactic cranial irradiation (PCI) is considered for high-risk cases, while MRI surveillance is preferred for select patients to reduce neurotoxicity.

Episodes in this series

2 experts in this video

EP. 1 An Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 The Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 An Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead With SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 The Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapies in Early-Stage NSCLC

2 experts in this video

EP. 7 The New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating the New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for the Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 The Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for the Advanced NSCLC

Video content above is prompted by the following:

How are you incorporating the ADRIATIC regimen into your clinical practice?
What is the role of immunotherapy in patients with LS-SCLC and paraneoplastic syndromes or immune disorders, and how might you approach treatment in this patient subgroup?
What is the role of prophylactic cranial radiation in LS-SCLC? In which patients would you consider PCI vs MRI surveillance alone?

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