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Opinion|Videos|March 12, 2025

The Key Updates in the Treatment of ES-SCLC

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how recent real-world data comparing atezolizumab and durvalumab in extensive-stage non–small cell lung cancer (ES-NSCLC) informs treatment selection, though direct comparisons remain limited. Lurbinectedin is a key second-line option, with emerging combination strategies.

Episodes in this series

2 experts in this video

EP. 1 An Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 The Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 An Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead With SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 The Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapies in Early-Stage NSCLC

2 experts in this video

EP. 7 The New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating the New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for the Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 The Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for the Advanced NSCLC

Video content above is prompted by the following:

What are your perceptions on recent retrospective real-world data comparing atezolizumab and durvalumab, and how do you incorporate these findings into your treatment decision making in patients with ES-NSCLC?
Briefly discuss the role of lurbinectedin in the second-line treatment setting. How are you incorporating lurbinectedin into your treatment approach, and what is the potential role of novel lurbinectedin-based combination strategies?

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