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Opinion|Videos|March 12, 2025

An Expert Perspectives on Tarlatamab in ES-SCLC

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how the DeLLphi-301 trial demonstrated that tarlatamab, administered biweekly at a 10 mg dose, achieved a 40% objective response rate in patients with previously treated extensive-stage small cell lung cancer (ES-SCLC). This led to its accelerated FDA approval in May 2024. Integrating tarlatamab into clinical practice may present challenges, including managing cytokine release syndrome and neurologic toxicities, as well as addressing financial considerations.

Episodes in this series

2 experts in this video

EP. 1 An Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 The Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 An Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead With SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 The Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapies in Early-Stage NSCLC

2 experts in this video

EP. 7 The New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating the New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for the Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 The Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for the Advanced NSCLC

Video content above is prompted by the following:

What are your thoughts on the latest data from DeLLphi-301 trial and the recent approval of tarlatamab in this setting?
How do intracranial efficacy data demonstrated with tarlatamab influence your treatment approach in patients with ES-SCLC and central nervous system involvement?
What are the key barriers to incorporating tarlatamab into your clinical practice (resources, educational needs, finances, etc)?

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