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Opinion|Videos|March 14, 2025

Navigating the New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how the MARIPOSA trial (ASCO 2024) showed improved overall survival (OS) with amivantamab plus lazertinib vs osimertinib in first-line EGFR-mutant non–small cell lung cancer (NSCLC), supporting its FDA approval (October 2024). This regimen may become standard of care for select patients, but osimertinib with or without chemo remains vital. The complete response letter (CRL) for subcutaneous amivantamab may delay uptake.

Episodes in this series

2 experts in this video

EP. 1 An Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 The Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 An Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead With SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 The Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapies in Early-Stage NSCLC

2 experts in this video

EP. 7 The New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating the New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for the Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 The Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for the Advanced NSCLC

Video content above is prompted by the following:

Briefly comment on the latest OS data from MARIPOSA andthe recentFDA approval (October 2024) of combination amivantamab and lazertinib as an advancement in the first-line treatment space.
MARIPOSA Felip E, et al. ASCO 2024. Abs 8504; J&J press release, January 7, 2025
Should this combination become the new standard of care for first-line treatment for certain patients?
What is the remaining role for osimertinib with or without chemotherapy?
How might the recent CRL for subcutaneous amivantamab impact clinical practice over the next year?

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