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Opinion|Videos|March 12, 2025

Looking Ahead With SCLC: ADCs and Other Novel Agents

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how emerging antibody-drug conjugate (ADC) data from TROPiCS-03 and IDeate-Lung01 suggest potential in extensive-stage small cell lung cancer (ES-SCLC), impacting sequencing with current therapies. T-cell engagers like BI 764532 and HPN328 may reshape treatment. MRI surveillance, per retrospective data and MAVERICK, offers an alternative to prophylactic cranial irradiation (PCI), though select factors may still justify PCI use.

Episodes in this series

2 experts in this video

EP. 1 An Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 The Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 An Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead With SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 The Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapies in Early-Stage NSCLC

2 experts in this video

EP. 7 The New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating the New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for the Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 The Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for the Advanced NSCLC

Video content above is prompted by the following:

What is your perspective on the emerging data for ADCs in this space? Where might these fit into the evolving treatment paradigm, and how would you sequence them with other available therapies?
TROPiCS-03 (Saci): Dowlati A, et al. WCLC 2024. Abs OA04.04
I-DXd (IDeate-Lung01): Rudin CM, et al. WCLC 2024. Abs OA04
What are your thoughts on current strategies and emerging data surrounding T-cell engagers, and how might they impact the treatment landscape?
BI 764532 (DAREON-8): Peters S, et al. ASCO 2024. Abs TPS8127
HPN328: Choudhury N, et al. ESMO 2023. Abs 698P
What evidence supports MRI surveillance as an alternative to PCI for brain metastasis management in ES-SCLC? What factors might still warrant PCI?
Retrospective data: Chen Y, et al. Respir Res. 2022;23:274.
MAVERICK trial: NCT04155034

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