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Opinion|Videos|October 28, 2024

Biomarker Testing in Advanced Endometrial Cancer: Approach, Key Markers, and Impact on Treatment Decisions

Author(s)Angeles Alvarez Secord, MD, MHSc , Dana M. Chase, MD, FACOG, Bhavana Pothuri, MD

Panelists discuss their approach to biomarker testing in advanced endometrial cancer, including the timing and types of testing performed, the specific biomarkers assessed (such as mismatch repair/microsatellite instability, POLE, and TP53), and how these results inform treatment decisions.

Episodes in this series

5 KOLs are featured in this series.

EP. 1 Approaching Biomarker Testing and Frontline Maintenance Therapy for Advanced Ovarian Cancer

5 KOLs are featured in this series.

EP. 2 Key Findings from the PRIMA Trial: Niraparib in 1L Maintenance for Advanced Ovarian Cancer

5 KOLs are featured in this series.

EP. 3 Duration of PARP Inhibitor Maintenance Therapy for Ovarian Cancer

5 KOLs are featured in this series.

EP. 4 Emerging Combinations in Maintenance Therapy for Ovarian Cancer

5 KOLs are featured in this series.

EP. 5 Optimizing Ovarian Cancer Care: PARP Resistance, Management of Oligoprogression, and Adverse Event Mitigation

5 KOLs are featured in this series.

EP. 6 Use of Trastuzumab Deruxtecan in Ovarian Cancer

5 KOLs are featured in this series.

EP. 7 Antibody-Drug Conjugates in Ovarian Cancer: Emerging Data and Treatment Integration

5 KOLs are featured in this series.

EP. 8 Navigating Treatment Strategies for Advanced Cervical Cancer: Localized Therapy, KEYNOTE-A18 Trial Data, and Frontline Approaches

5 KOLs are featured in this series.

EP. 9 Integrating Tisotumab Vedotin into Ovarian Cancer Therapy

5 KOLs are featured in this series.

EP. 10 Biomarker Testing in Advanced Endometrial Cancer: Approach, Key Markers, and Impact on Treatment Decisions

5 KOLs are featured in this series.

EP. 11 Managing Recurrent Endometrial Cancer: Treatment Strategies and RUBY Trial Insights

5 KOLs are featured in this series.

EP. 12 Durvalumab in Endometrial Cancer: DUO-E Trial Updates

5 KOLs are featured in this series.

EP. 13 Innovative Combination Strategies for Endometrial Cancer: Updates from LEAP and KEYNOTE-B21 Trials

5 KOLs are featured in this series.

EP. 14 T-DXd in Advanced Endometrial Cancer

5 KOLs are featured in this series.

EP. 15 Emerging ADCs in Advanced Endometrial Cancer: Anti-TROP2 and Anti-FR Agents

Video content above is prompted by the following:

How do you typically approach biomarker testing for advanced endometrial cancer?

When do you test/retest, and what type of testing do you perform?
Which biomarkers do you generally access (eg, mismatch repair/microsatellite instability, POLE, TP53, etc) and how do results help guide your treatment approach?

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