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Opinion|Videos|November 4, 2024

Managing Recurrent Endometrial Cancer: Treatment Strategies and RUBY Trial Insights

Author(s)Angeles Alvarez Secord, MD, MHSc , Dana M. Chase, MD, FACOG, Bhavana Pothuri, MD

Panelists review available treatment options for recurrent endometrial cancer, discussing their typical treatment approaches and the factors influencing treatment selection. Panelists also address insights from the RUBY trial, its updates, and the expanded FDA indication for dostarlimab, including the implications of these developments on treatment strategies and the potential benefits and challenges of broader use in patients.

Episodes in this series

5 KOLs are featured in this series.

EP. 1 Approaching Biomarker Testing and Frontline Maintenance Therapy for Advanced Ovarian Cancer

5 KOLs are featured in this series.

EP. 2 Key Findings from the PRIMA Trial: Niraparib in 1L Maintenance for Advanced Ovarian Cancer

5 KOLs are featured in this series.

EP. 3 Duration of PARP Inhibitor Maintenance Therapy for Ovarian Cancer

5 KOLs are featured in this series.

EP. 4 Emerging Combinations in Maintenance Therapy for Ovarian Cancer

5 KOLs are featured in this series.

EP. 5 Optimizing Ovarian Cancer Care: PARP Resistance, Management of Oligoprogression, and Adverse Event Mitigation

5 KOLs are featured in this series.

EP. 6 Use of Trastuzumab Deruxtecan in Ovarian Cancer

5 KOLs are featured in this series.

EP. 7 Antibody-Drug Conjugates in Ovarian Cancer: Emerging Data and Treatment Integration

5 KOLs are featured in this series.

EP. 8 Navigating Treatment Strategies for Advanced Cervical Cancer: Localized Therapy, KEYNOTE-A18 Trial Data, and Frontline Approaches

5 KOLs are featured in this series.

EP. 9 Integrating Tisotumab Vedotin into Ovarian Cancer Therapy

5 KOLs are featured in this series.

EP. 10 Biomarker Testing in Advanced Endometrial Cancer: Approach, Key Markers, and Impact on Treatment Decisions

5 KOLs are featured in this series.

EP. 11 Managing Recurrent Endometrial Cancer: Treatment Strategies and RUBY Trial Insights

5 KOLs are featured in this series.

EP. 12 Durvalumab in Endometrial Cancer: DUO-E Trial Updates

5 KOLs are featured in this series.

EP. 13 Innovative Combination Strategies for Endometrial Cancer: Updates from LEAP and KEYNOTE-B21 Trials

5 KOLs are featured in this series.

EP. 14 T-DXd in Advanced Endometrial Cancer

5 KOLs are featured in this series.

EP. 15 Emerging ADCs in Advanced Endometrial Cancer: Anti-TROP2 and Anti-FR Agents

Video content above is prompted by the following:

Briefly review the available treatment options for recurrent endometrial cancer.
What is your typical treatment approach for patients with recurrent endometrial cancer, and what factors drive your treatment selection?
In which patients do you opt for single-agent immunotherapy (IO) vs chemotherapy + IO, and what is your underlying rationale?
Talking points: RUBY trial, part 2 of RUBY trial, GY018, DUO-E
Dostarlimab, durvalumab + carboplatin + paclitaxel +/- olaparib, pembrolizumab
Briefly comment on recent data updates presented for the RUBY trial and offer insights into the expanded FDA indication for dostarlimab in endometrial cancer.
Briefly comment on key takeaways from extended efficacy and safety data leading to the expanded approval.
How does the expanded indication approved for dostarlimab impact your treatment approach for advanced or recurrent endometrial cancer?
What are the potential benefits and challenges of using dostarlimab in a broader patient population?

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