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Opinion|Videos|January 13, 2026

Data for Out-of-Specification Cilta-Cel in R/R Multiple Myeloma

Author(s)Maximilian Merz, MD, Carrie Bellerive, BS, RN, BMTCN

Maximilian Merz, MD, and Carrie Bellerive, BS, RN, BMTCN, detail data for out-of-specification cilta-cel in multiple myeloma, as presented at ASH 2025.

Episodes in this series

EP. 1 How CAR T-Cell Therapy Has Affected Clinical Management of Multiple Myeloma

EP. 1 How CAR T-Cell Therapy Has Affected Clinical Management of Multiple Myeloma

EP. 2 The Role of Treatment Center Coordinators for CAR T-Cell Therapy Administration in Myeloma

EP. 2 The Role of Treatment Center Coordinators for CAR T-Cell Therapy Administration in Myeloma

EP. 3 Current Expectations With Commercial Manufacturing of CAR T-Cell Therapy

EP. 3 Current Expectations With Commercial Manufacturing of CAR T-Cell Therapy

EP. 4 Navigating Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

EP. 4 Navigating Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

EP. 5 Data for Out-of-Specification Cilta-Cel in R/R Multiple Myeloma

EP. 5 Data for Out-of-Specification Cilta-Cel in R/R Multiple Myeloma

EP. 6 Key Updates With CAR T-Cell Therapy in Myeloma From ASH 2025

EP. 6 Key Updates With CAR T-Cell Therapy in Myeloma From ASH 2025

EP. 7 Pressing Questions to Address With Ongoing Research With CAR T-Cell Therapy in Myeloma

EP. 7 Pressing Questions to Address With Ongoing Research With CAR T-Cell Therapy in Myeloma

Maximilian Merz, MD, and Carrie Bellerive, BS, RN, BMTCN, review data presented at ASH 2025 evaluating out-of-specification ciltacabtagene autoleucel (cilta-cel; Carvykti) in relapsed/refractory multiple myeloma. They discuss efficacy and safety outcomes and how these findings may inform clinical decision-making when manufacturing parameters fall outside standard specifications. Merz and Bellerive provide perspective on how these data for cilta-cel may expand treatment opportunities for select patients.

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