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Opinion|Videos|December 22, 2025

How CAR T-Cell Therapy Has Affected Clinical Management of Multiple Myeloma

Author(s)Maximilian Merz, MD, Carrie Bellerive, BS, RN, BMTCN

Maximilian Merz, MD, and Carrie Bellerive, BS, RN, BMTCN, discuss how agents such as cilta-cel and ide-cel have affected multiple myeloma management.

Episodes in this series

EP. 1 How CAR T-Cell Therapy Has Affected Clinical Management of Multiple Myeloma

EP. 1 How CAR T-Cell Therapy Has Affected Clinical Management of Multiple Myeloma

EP. 2 The Role of Treatment Center Coordinators for CAR T-Cell Therapy Administration in Myeloma

EP. 2 The Role of Treatment Center Coordinators for CAR T-Cell Therapy Administration in Myeloma

EP. 3 Current Expectations With Commercial Manufacturing of CAR T-Cell Therapy

EP. 3 Current Expectations With Commercial Manufacturing of CAR T-Cell Therapy

EP. 4 Navigating Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

EP. 4 Navigating Bridging Therapy With CAR T-Cell Therapy in Multiple Myeloma

EP. 5 Data for Out-of-Specification Cilta-Cel in R/R Multiple Myeloma

EP. 5 Data for Out-of-Specification Cilta-Cel in R/R Multiple Myeloma

EP. 6 Key Updates With CAR T-Cell Therapy in Myeloma From ASH 2025

EP. 6 Key Updates With CAR T-Cell Therapy in Myeloma From ASH 2025

EP. 7 Pressing Questions to Address With Ongoing Research With CAR T-Cell Therapy in Myeloma

EP. 7 Pressing Questions to Address With Ongoing Research With CAR T-Cell Therapy in Myeloma

Maximilian Merz, MD, and Carrie Bellerive, BS, RN, BMTCN, discuss how CAR T-cell therapies such as ciltacabtagene autoleucel (Carvykti) and idecabtagene vicleucel (Abecma) have reshaped the treatment landscape for multiple myeloma. They review how these agents have influenced sequencing decisions, referral patterns, and expectations for depth and durability of response. Merz and Bellerive also address how CAR T-cell therapy has altered multidisciplinary care models in routine clinical practice.

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