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Opinion|Videos|December 22, 2025

How CAR T-Cell Therapy Has Affected Clinical Management of Multiple Myeloma

Maximilian Merz, MD, and Carrie Bellerive, BS, RN, BMTCN, discuss how agents such as cilta-cel and ide-cel have affected multiple myeloma management.

Maximilian Merz, MD, and Carrie Bellerive, BS, RN, BMTCN, discuss how CAR T-cell therapies such as ciltacabtagene autoleucel (Carvykti) and idecabtagene vicleucel (Abecma) have reshaped the treatment landscape for multiple myeloma. They review how these agents have influenced sequencing decisions, referral patterns, and expectations for depth and durability of response. Merz and Bellerive also address how CAR T-cell therapy has altered multidisciplinary care models in routine clinical practice.

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