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Opinion|Videos|November 10, 2025

Dermatology’s Role in Diagnosing and Managing cSCC

Panelists discuss how dermatologists serve as the first line of detection and play an essential role in early management and triage of cSCC.

Dermatologists often diagnose and manage early-stage cutaneous squamous cell carcinoma (cSCC) directly through excision, curettage, or Mohs surgery. Panelists note that familiarity with histopathologic patterns allows for rapid intervention and accurate classification. For higher-risk lesions, dermatologists coordinate with surgical, radiation, and medical oncology colleagues to ensure appropriate staging and treatment planning.

Challenges arise when differentiating between atypical keratinocytic lesions and invasive carcinoma, particularly in previously treated or irradiated skin. Access to in-office pathology and standardized reporting assists in clinical decision-making.

Overall, the panel underscores that dermatology is the gateway to multidisciplinary cSCC care. Timely communication between dermatologists and referral centers ensures seamless escalation for complex cases and prevents treatment delays.

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