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Opinion|Videos|November 10, 2025

Role of Radiotherapy in Managing cSCC

Author(s)Soo Park, MD, Vishal A. Patel, MD, FAAD, FACMS, Neil D. Gross, MD, FACS

Panelists discuss when radiation therapy is appropriate for treating cSCC, and how it complements surgical management.

Episodes in this series

4 panelists

EP. 1 Approach to Evaluating Suspected cSCC

4 panelists

EP. 2 Assessing Risk in cSCC: Key Clinical and Pathologic Markers

4 panelists

EP. 3 Dermatology’s Role in Diagnosing and Managing cSCC

4 panelists

EP. 4 Balancing In-Clinic Treatment and Referral in cSCC

4 panelists

EP. 5 Applying Guideline-Based Care Pathways in cSCC

4 panelists

EP. 6 Recognizing High-Risk cSCC Patients for Early Biopsy

4 panelists

EP. 7 Defining Primary Treatment Options in cSCC

4 panelists

EP. 8 Identifying Surgical Candidates in cSCC

4 panelists

EP. 9 Role of Radiotherapy in Managing cSCC

4 panelists

EP. 10 Integrating Systemic Therapy Into cSCC Management

4 panelists

EP. 11 The Evolving Role of Adjuvant Immunotherapy

4 panelists

EP. 12 Selecting Candidates for Adjuvant Immunotherapy in cSCC

4 panelists

EP. 13 Clinical Trial Design and Outcomes in Adjuvant Immunotherapy for cSCC

4 panelists

EP. 14 Long-Term Follow-Up and Surveillance After Adjuvant Therapy

4 panelists

EP. 15 Optimizing Multidisciplinary Collaboration in cSCC Care

Radiation therapy serves as both a definitive and adjuvant option in cutaneous squamous cell carcinoma (cSCC) management. Panelists note that it is particularly valuable for patients with positive margins, perineural invasion, or inoperable disease due to medical or anatomic limitations.

The conversation covers dose planning, balancing efficacy with skin toxicity, and using radiotherapy postoperatively to reduce recurrence. Advances in image-guided and hypofractionated techniques have expanded its role, particularly for elderly or frail patients.

They conclude that radiation therapy remains a key pillar of multidisciplinary cSCC care, often enabling durable control where surgery alone may be insufficient.

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