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Opinion|Videos|November 10, 2025

Identifying Surgical Candidates in cSCC

Author(s)Soo Park, MD, Vishal A. Patel, MD, FAAD, FACMS, Neil D. Gross, MD, FACS

Panelists discuss how to identify appropriate surgical candidates and coordinate timely referral to specialized surgical teams.

Episodes in this series

4 panelists

EP. 1 Approach to Evaluating Suspected cSCC

4 panelists

EP. 2 Assessing Risk in cSCC: Key Clinical and Pathologic Markers

4 panelists

EP. 3 Dermatology’s Role in Diagnosing and Managing cSCC

4 panelists

EP. 4 Balancing In-Clinic Treatment and Referral in cSCC

4 panelists

EP. 5 Applying Guideline-Based Care Pathways in cSCC

4 panelists

EP. 6 Recognizing High-Risk cSCC Patients for Early Biopsy

4 panelists

EP. 7 Defining Primary Treatment Options in cSCC

4 panelists

EP. 8 Identifying Surgical Candidates in cSCC

4 panelists

EP. 9 Role of Radiotherapy in Managing cSCC

4 panelists

EP. 10 Integrating Systemic Therapy Into cSCC Management

4 panelists

EP. 11 The Evolving Role of Adjuvant Immunotherapy

4 panelists

EP. 12 Selecting Candidates for Adjuvant Immunotherapy in cSCC

4 panelists

EP. 13 Clinical Trial Design and Outcomes in Adjuvant Immunotherapy for cSCC

4 panelists

EP. 14 Long-Term Follow-Up and Surveillance After Adjuvant Therapy

4 panelists

EP. 15 Optimizing Multidisciplinary Collaboration in cSCC Care

Panelists explain that surgery remains the preferred option for most resectable high-risk cutaneous squamous cell carcinoma (cSCC). Ideal candidates are those with localized disease, good performance status, and lesions that can be excised with functional and aesthetic preservation.

They emphasize the importance of early referral to head and neck or reconstructive surgeons for complex or recurrent cases, where achieving clear margins is critical. Multidisciplinary consultation can determine whether surgery alone suffices or if adjuvant treatment is warranted.

The discussion reinforces that integrating surgery early within a coordinated care model maximizes both local control and quality of life for patients.

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