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Opinion|Videos|November 10, 2025

Integrating Systemic Therapy Into cSCC Management

Author(s)Soo Park, MD, Vishal A. Patel, MD, FAAD, FACMS, Neil D. Gross, MD, FACS

Panelists discuss the growing use of systemic immunotherapy for advanced or unresectable cSCC and how it integrates with other modalities.

Episodes in this series

4 panelists

EP. 1 Approach to Evaluating Suspected cSCC

4 panelists

EP. 2 Assessing Risk in cSCC: Key Clinical and Pathologic Markers

4 panelists

EP. 3 Dermatology’s Role in Diagnosing and Managing cSCC

4 panelists

EP. 4 Balancing In-Clinic Treatment and Referral in cSCC

4 panelists

EP. 5 Applying Guideline-Based Care Pathways in cSCC

4 panelists

EP. 6 Recognizing High-Risk cSCC Patients for Early Biopsy

4 panelists

EP. 7 Defining Primary Treatment Options in cSCC

4 panelists

EP. 8 Identifying Surgical Candidates in cSCC

4 panelists

EP. 9 Role of Radiotherapy in Managing cSCC

4 panelists

EP. 10 Integrating Systemic Therapy Into cSCC Management

4 panelists

EP. 11 The Evolving Role of Adjuvant Immunotherapy

4 panelists

EP. 12 Selecting Candidates for Adjuvant Immunotherapy in cSCC

4 panelists

EP. 13 Clinical Trial Design and Outcomes in Adjuvant Immunotherapy for cSCC

4 panelists

EP. 14 Long-Term Follow-Up and Surveillance After Adjuvant Therapy

4 panelists

EP. 15 Optimizing Multidisciplinary Collaboration in cSCC Care

Panelists highlight that immune checkpoint inhibition has transformed the management of advanced cutaneous squamous cell carcinoma (cSCC), providing durable responses and improved survival. Candidates include patients with locally advanced or metastatic disease not amenable to surgery or radiation.

Integration requires coordination between dermatology, oncology, and surgical teams to determine sequencing and manage immune-related adverse events. Multidisciplinary tumor boards ensure alignment between systemic and local therapy.

They conclude that systemic therapy now represents a pivotal component of comprehensive cSCC management, bridging curative and palliative intent with meaningful clinical benefit.

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