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Opinion|Videos|November 25, 2025

Disease State Information on TNBC

Author(s)Neil M. Iyengar, MD, Kelly E. McCann, MD, PhD, Kamel Abou Hussein, MD

Panelists discuss how molecular characterization and novel agents are redefining the management of TNBC.

Episodes in this series

Experts featured in this series.

EP. 1 Background Information on Targeted Therapies in Breast Cancer

Experts featured in this series.

EP. 2 Clinical Trial Evidence for HER2-Targeted Therapies in Early Breast Cancer

Experts featured in this series.

EP. 3 The Role of ADCs in Different Subgroups

Experts featured in this series.

EP. 4 First-Line Treatment Regimens in Metastatic HER2+ Breast Cancer

Experts featured in this series.

EP. 5 Treatment Sequencing in Later Lines of Therapy in HER2+ Metastatic Breast Cancer

Experts featured in this series.

EP. 6 Additional Data with HER2-Targeted Agents in Metastatic Breast Cancer

Experts featured in this series.

EP. 7 Treatment of HER2-Low and Future Therapies in Metastatic Breast Cancer

Experts featured in this series.

EP. 8 Disease State Information on TNBC

Experts featured in this series.

EP. 9 Exciting New Data for TNBC Therapies

Experts featured in this series.

EP. 10 Unmet Needs and Future Outlook for HER2-Targeted Therapies

Panelists discuss how:
Triple-negative breast cancer (TNBC) remains one of the most aggressive and difficult-to-treat subtypes. The experts outline its molecular heterogeneity, lack of hormone receptor targets, and poor prognosis. They describe evolving molecular profiling efforts that identify actionable mutations and biomarkers. The conversation emphasizes how immunotherapy, ADCsantibody-drug conjugates, and combination regimens are reshaping standard-of-care options and improving survival outcomes for this challenging population.

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