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Opinion|Videos|December 4, 2025

Exciting New Data for TNBC Therapies

Author(s)Neil M. Iyengar, MD, Kelly E. McCann, MD, PhD, Kamel Abou Hussein, MD

Panelists discuss how new trial results from ASCENT-03 and TROPION-Breast02 are shaping next-generation TNBC therapies.

Episodes in this series

Experts featured in this series.

EP. 1 Background Information on Targeted Therapies in Breast Cancer

Experts featured in this series.

EP. 2 Clinical Trial Evidence for HER2-Targeted Therapies in Early Breast Cancer

Experts featured in this series.

EP. 3 The Role of ADCs in Different Subgroups

Experts featured in this series.

EP. 4 First-Line Treatment Regimens in Metastatic HER2+ Breast Cancer

Experts featured in this series.

EP. 5 Treatment Sequencing in Later Lines of Therapy in HER2+ Metastatic Breast Cancer

Experts featured in this series.

EP. 6 Additional Data with HER2-Targeted Agents in Metastatic Breast Cancer

Experts featured in this series.

EP. 7 Treatment of HER2-Low and Future Therapies in Metastatic Breast Cancer

Experts featured in this series.

EP. 8 Disease State Information on TNBC

Experts featured in this series.

EP. 9 Exciting New Data for TNBC Therapies

Experts featured in this series.

EP. 10 Unmet Needs and Future Outlook for HER2-Targeted Therapies

Panelists discuss how:
Rrecent ESMOEuropean Society for Medical Oncology presentations revealed transformative findings for triple-negative breast cancer (TNBC) management. The ASCENT-03 and TROPION-Breast02 studies demonstrated significant efficacy of ADCantibody-drug conjugate-based and novel combination regimens, improving survival and tolerability. Panelists interpret the clinical implications, highlighting where these agents may fit in treatment algorithms. They stress the importance of real-world data and multidisciplinary coordination to ensure broad access and equitable benefits across diverse patient populations.

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