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Opinion|Videos|November 11, 2025

First-Line Treatment Regimens in Metastatic HER2+ Breast Cancer

Author(s)Neil M. Iyengar, MD, Kelly E. McCann, MD, PhD, Kamel Abou Hussein, MD

Panelists discuss how evolving first-line HER2-targeted combinations are improving outcomes and redefining standards in metastatic breast cancer..

Episodes in this series

Experts featured in this series.

EP. 1 Background Information on Targeted Therapies in Breast Cancer

Experts featured in this series.

EP. 2 Clinical Trial Evidence for HER2-Targeted Therapies in Early Breast Cancer

Experts featured in this series.

EP. 3 The Role of ADCs in Different Subgroups

Experts featured in this series.

EP. 4 First-Line Treatment Regimens in Metastatic HER2+ Breast Cancer

Experts featured in this series.

EP. 5 Treatment Sequencing in Later Lines of Therapy in HER2+ Metastatic Breast Cancer

Experts featured in this series.

EP. 6 Additional Data with HER2-Targeted Agents in Metastatic Breast Cancer

Experts featured in this series.

EP. 7 Treatment of HER2-Low and Future Therapies in Metastatic Breast Cancer

Experts featured in this series.

EP. 8 Disease State Information on TNBC

Experts featured in this series.

EP. 9 Exciting New Data for TNBC Therapies

Experts featured in this series.

EP. 10 Unmet Needs and Future Outlook for HER2-Targeted Therapies

Panelists discuss how:
Current first-line standards continue to evolve with improved targeted combinations for metastatic HER2-positive breast cancer. They review pivotal data supporting dual HER2 blockade, antibody–-drug conjugates, and optimized chemotherapy backbones. The conversation emphasizes tailoring regimens to patient-specific disease burden, comorbidities, and tolerance profiles. Safety, durability of response, and sequence planning are explored, highlighting the need for continual reassessment as new trials report outcomes.

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