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Opinion|Videos|December 4, 2025

Unmet Needs and Future Outlook for HER2-Targeted Therapies

Author(s)Neil M. Iyengar, MD, Kelly E. McCann, MD, PhD, Kamel Abou Hussein, MD

Panelists discuss how innovative HER2-targeted strategies and precision approaches will define the next era of breast cancer therapy.

Episodes in this series

Experts featured in this series.

EP. 1 Background Information on Targeted Therapies in Breast Cancer

Experts featured in this series.

EP. 2 Clinical Trial Evidence for HER2-Targeted Therapies in Early Breast Cancer

Experts featured in this series.

EP. 3 The Role of ADCs in Different Subgroups

Experts featured in this series.

EP. 4 First-Line Treatment Regimens in Metastatic HER2+ Breast Cancer

Experts featured in this series.

EP. 5 Treatment Sequencing in Later Lines of Therapy in HER2+ Metastatic Breast Cancer

Experts featured in this series.

EP. 6 Additional Data with HER2-Targeted Agents in Metastatic Breast Cancer

Experts featured in this series.

EP. 7 Treatment of HER2-Low and Future Therapies in Metastatic Breast Cancer

Experts featured in this series.

EP. 8 Disease State Information on TNBC

Experts featured in this series.

EP. 9 Exciting New Data for TNBC Therapies

Experts featured in this series.

EP. 10 Unmet Needs and Future Outlook for HER2-Targeted Therapies

Panelists discuss how:
Despite major progress, unmet needs persist in optimizing HER2-targeted treatment sequences and addressing resistance mechanisms. The experts explore how next-generation ADCsantibody-drug conjugates, bispecific antibodies, and HER3-targeted drugs may close therapeutic gaps. They emphasize ongoing clinical trials that aim to extend the benefits into HER2-low and resistant populations. The discussion concludes with optimism for integrating molecular diagnostics, real-world evidence, and multidisciplinary collaboration to continue improving patient outcomes.

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